O’Sullivan, Dylan

Preventive Oncology

Adjunct Assistant Professor

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CEPR

Biography

Dr. Dylan O’Sullivan is a cancer epidemiologist and health services researcher in the Department of Cancer Epidemiology and Prevention Research (CEPR) of Cancer Care Alberta and an adjunct assistant professor in the Departments of Oncology and Community Health Sciences at the University of Calgary. He has a broad research program focused on reducing the burden of cancer across the cancer control continuum with the use of big data and novel data analytics. His primary research interests include the etiology of early-onset cancers, risk-stratified approaches to screening, and understanding the risk of developing subsequent primary cancers among cancer survivors.

Dr. O’Sullivan joined the department in December 2022 and to date has published close to 100 peer-reviewed manuscripts in leading scholarly journals of oncology and epidemiology. He is currently establishing a research program around precision prevention, screening, and follow-up surveillance of cancer survivors for subsequent primary cancers using cohort and administrative data sources. His research program involves collaborations with researchers across multiple disciplines including computer scientists, qualitative researchers, molecular epidemiologists, medical oncologists, cancer screening experts, and patient advisors.

Dr. O’Sullivan completed a BA in Sociology at Dartmouth College (2015) and worked there as a molecular epidemiology research assistant for Dr Brock Christensen. Subsequently, he completed a mini-Master’s in Epidemiology (2016) and PhD in Public Health Sciences (Epidemiology) from Queen’s University in 2020, where his work focused on population attributable risk estimation and etiologic research using data from both case-control and prospective cohort studies. He then completed a 2-year CIHR-funded postdoctoral fellowship at the University of Calgary conducting interdisciplinary research on reducing incidence and improving outcomes of early-onset colorectal cancer patients. During his postdoctoral fellowship, he also collaborated extensively with clinician scientists on several real-world oncology outcome studies.

Area of Focus

Epidemiology, Survivorship, Subsequent primary cancers, Cancer screening, Cancer prevention, Real-world evidence

Summary of Research

Warkentin MT, Brenner DR, Cheung WY, O’Sullivan DE. The risk of a subsequent primary cancer among cancer survivors. Cancer Epidemiol Biomarkers and Prev. 2025 Jan 9;34(1):174-181. doi: 10.1158/1055-9965.EPI-24-0636.

Bista S, Khan M, Nambayan R, Ruan Y, Hilsden RJ, Brenner DR, O’Sullivan DE. Colorectal cancer screening among non-colorectal cancer survivors: a systematic review and meta-analysis. Am J Prev Med. 2025 Dec 23;70(5):108239. doi: 10.1016/j.amepre.2025.108239.

Bista S, Harsanyi H, Khan M, Nambayan R, Ruan Y, Hilsden RJ, Brenner DR, O’Sullivan DE. Breast cancer screening among cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol, Biomarkers Prev. 2026 Apr 1;35(4):506-518. doi: 10.1158/1055-9965.EPI-25-1465.

Kokts-Porietis R, O’Sullivan DE, Nelson G, Courneya KS, Cook LS, Friedenreich CM. Risk factors for second primary cancer in a prospective cohort of endometrial cancer survivors: an Alberta endometrial cancer cohort study. Am J of Epidemiol. 2024 Jun 24:kwae140. doi:10.1093/aje/kwae140.

O’Sullivan DE, Ruan Y, Hutchinson J, Farah E, Hilsden RJ, Brenner DR. Risk factors for early-onset colorectal cancer: An analysis of Canadian prospective cohort studies. Cancer Epidemiol. 2024 Aug;91:102578. doi: 10.1016/j.canep.2024.102578.

O’Sullivan DE, Sutherland R, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR. Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis. Clin Gastroenterol and Hepatol. 2021 Jan 29:S1542-3565(21)00087-2. Doi: 10.1016/j.cgh.2021.01.037.

Hanna TP, King WD, Thibodeau S, Jalink M, Paulin G, Harvey-Jones, O’Sullivan DE, Booth CM, Sullivan R, Aggarwal A. Mortality due to cancer treatment delay: A systematic review and meta-analysis. BMJ. 2020 Nov 4;371:m4087. doi: 10.1136/bmj.m4087.

Poirier AE, Ruan Y, Volesky KD, King WD, O’Sullivan DE, Gogna P, Walter SD, Villeneuve PJ, Friedenreich CM and Brenner DR on behalf of the ComPARe Study Team. The current and future burden of cancers attributable to modifiable risk factors in Canada: Summary of results. Prev Med. 2019 May;122:140-147. doi: 10.1016/j.ypmed.2019.04.007

Area Of Focus

Epidemiology, Survivorship, Subsequent primary cancers, Cancer screening, Cancer prevention, Real-world evidence

Summary Of Research

Warkentin MT, Brenner DR, Cheung WY, O’Sullivan DE. The risk of a subsequent primary cancer among cancer survivors. Cancer Epidemiol Biomarkers and Prev. 2025 Jan 9;34(1):174-181. doi: 10.1158/1055-9965.EPI-24-0636.

Bista S, Khan M, Nambayan R, Ruan Y, Hilsden RJ, Brenner DR, O’Sullivan DE. Colorectal cancer screening among non-colorectal cancer survivors: a systematic review and meta-analysis. Am J Prev Med. 2025 Dec 23;70(5):108239. doi: 10.1016/j.amepre.2025.108239.

Bista S, Harsanyi H, Khan M, Nambayan R, Ruan Y, Hilsden RJ, Brenner DR, O’Sullivan DE. Breast cancer screening among cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol, Biomarkers Prev. 2026 Apr 1;35(4):506-518. doi: 10.1158/1055-9965.EPI-25-1465.

Kokts-Porietis R, O’Sullivan DE, Nelson G, Courneya KS, Cook LS, Friedenreich CM. Risk factors for second primary cancer in a prospective cohort of endometrial cancer survivors: an Alberta endometrial cancer cohort study. Am J of Epidemiol. 2024 Jun 24:kwae140. doi:10.1093/aje/kwae140.

O’Sullivan DE, Ruan Y, Hutchinson J, Farah E, Hilsden RJ, Brenner DR. Risk factors for early-onset colorectal cancer: An analysis of Canadian prospective cohort studies. Cancer Epidemiol. 2024 Aug;91:102578. doi: 10.1016/j.canep.2024.102578.

O’Sullivan DE, Sutherland R, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR. Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis. Clin Gastroenterol and Hepatol. 2021 Jan 29:S1542-3565(21)00087-2. Doi: 10.1016/j.cgh.2021.01.037.

Hanna TP, King WD, Thibodeau S, Jalink M, Paulin G, Harvey-Jones, O’Sullivan DE, Booth CM, Sullivan R, Aggarwal A. Mortality due to cancer treatment delay: A systematic review and meta-analysis. BMJ. 2020 Nov 4;371:m4087. doi: 10.1136/bmj.m4087.

Poirier AE, Ruan Y, Volesky KD, King WD, O’Sullivan DE, Gogna P, Walter SD, Villeneuve PJ, Friedenreich CM and Brenner DR on behalf of the ComPARe Study Team. The current and future burden of cancers attributable to modifiable risk factors in Canada: Summary of results. Prev Med. 2019 May;122:140-147. doi: 10.1016/j.ypmed.2019.04.007