Cuvelier, Geoff

Paediatric Oncology

Clinical Professor

Biography

Dr. Geoff Cuvelier is the Section Chief for Pediatric Oncology and Transplant at the Alberta Children’s Hospital, a Pediatric Oncologist and Hematopoietic Cell Therapy specialist, and a Clinical Professor of Pediatrics and Oncology at the University of Calgary, Cumming School of Medicine. He has been involved in many aspects of childhood cancer care both locally and nationally, including serving on the executive of the national organization C17, as a co-lead for the ACCESS program promoting access to innovative therapies for children with cancer across Canada, and serving on the National Task force for improving Adolescent and Young Adult cancer control. As a researcher, he has been involved in pediatric chronic graft-versus-host disease (GVHD) following hematopoietic cell transplant, including leadership roles in the Applied Biomarkers of Late Effects of Childhood Cancer study that included understanding clinical and biologic aspects of pediatric chronic GVHD, as well as being part of the 2020 National Institutes of Health chronic GVHD consensus, where he led the atypical chronic GVHD task force. He is the current co-chair of the GVHD committee within the Pediatric Transplant and Cellular Therapy Consortium. He has also had interest in hematopoietic cell transplant for primary immunodeficiency diseases in infants and children, publishing the largest experience with adenosine deaminase severe combined immune deficiency to date. He is the current co-lead of the Primary Immune Deficiency Treatment Consortium 6907 study of severe combined immune deficiency.

Area of Focus

  • Pediatric Hematopoietic Cell Transplant
  • Chronic Graft-Versus-Host Disease in Children
  • Primary Immune Deficiency and Transplant Approaches and Outcomes

Summary of Research

  1. Bhatt NS, Harris AC, Gorfinkel L, Ibanez K, Tkaczyk ER, Mitchell SA, Albuquerque S, Schecter T, Pavletic S, Duncan CN, Rotz SJ, Williams K, Carpenter PA, Cuvelier GDE. “Pediatric Transplant and Cellular Therapy Consortium RESILIENT conference on pediatric chronic graft-versus-host disease survivorship after hematopoietic cell transplantation: Part I. Phases of chronic GVHD, supportive care, and systemic therapy discontinuation”.  Transplantation and Cellular Therapy.  Feb;31(2):69.e1-69.e18.  DOI: 10.1016/j.jtct.2024.12.011.  PMID: 39701289.  Senior Author.
  2. Pham-Huy A, Murguia-Favela L, Rubin T, Suresh S, Wright NAM, Derfalvi B, Sinha R, Bowes J, Cuvelier GDE. “Inborn errors of immunity in Canadian First Nations and Nunavut Inuit children: The tip of the iceberg”.  Paediatrics & Child Health. 2024.  Jun 13:30(1):40-47.  DOI: 10.1093/pch/pxae026.  PMID: 40061245.    Senior author.
  3. Cuvelier GDE, Ng B, Abdossamadi S, Nemecek ER, Melton A, Kitko CL, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, Ostroumov E, Schultz KR.  “A diagnostic classifier for pediatric chronic graft-versus-host disease: Results of the ABLE / PBMTC 1202 study”.  Blood Advances.  2023 July 25; 7(14):3612-3623.  DOI: 10.1182/bloodadvances.2022007715.  PMID: 36219586.  Corresponding author.
  4. Cuvelier GDE, Logan BR, Prockop SE, Buckley RH, Kuo CY, Griffith LM, Liu X, Yip A, Hershfield MS, Ayoub PG, Moore TB, Dorsey MJ, O’Reilly RJ, Kapoor N, Pai S-Y, Kapadia M, Ebens CL, Forbes-Satter LR, Burroughs LM, Petrovic A, Chellapandian D, Heimall J, Shyr DC, Rayes A, Bednarski JJ, Chandra S, Chandrakasan S, Gillio AP, Madden L, Quigg TC, Caywood EH, Dávila Saldaña BJ, DeSantes K, Eissa H, Goldman FD, Rozmus J, Shah AJ, Vander Lugt MT, Thakar MS, Parrott RE, Martinez C, Leiding JW, Torgerson TR, Pulsipher MA, Notarangelo LD, Cowan MJ, Dvorak CC, Haddad E, Puck JM, Kohn DB.  “Outcomes following treatment for adenosine deaminase deficient severe combined immune deficiency: A report from the PIDTC”.  Blood.  2022.  Aug 18; 140(7):685-705.  DOI: 10.1182/blood.2022016196.  PMID: 35671392.  Corresponding author.
  5. Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, Penack P, Santomasso BD, Zeiser R, Angstwurm K, MacDonald KPA, Kimberly WT, Bilic E, Banas B, Buettner-Herold M, Sinha N, Greinix HT, Pidala J, Schultz KR, Williams KM, Inamoto Y, Cutler C, Lee SJ,  Sarantopoulos S, Pavletic SZ, Wolff D.  “Towards a better understanding of the atypical manifestations of chronic graft-versus-host disease: A report from the 2020 National Institutes of Health Consensus Project Task Force”.  Transplantation and Cellular Therapy.  2022.  Aug; 28(8): 426-445.  DOI: 10.1016/j.jtct.2022.05.038.  PMID: 35662591.  Corresponding author.
  6. Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek E, Rozmus J, Kharbanda S, Kitko C, Lewis V, Schechter T, Jacobsohn D, Harris A, Pulsipher M, Bittencourt H, Choi SW, Caywood E, Kasow K, Bhatia M, Oshrine B, Coulter D, Chewning J, Joyce M, Pawlowska A, Megason G, Lawitschka A, Ostroumov E, Getlinik RK, Cuvelier GDE* and Schultz KR*.  “Metabolomic identification of alpha-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease”. Blood 2022. Jan 13;139(2):287-299. DOI: 10.1182/blood2021013244.  PMID: 34534280. *Co-Senior Author.
  7. Cuvelier GDE*, Li A*, Drissler S, Kariminia A, Abdossamadi S, Rozmus J, Ng B, Mostafavi S, Brinkman R, Schultz KR.  “Age related differences in the biology of chronic graft-versus-host disease after hematopoietic stem cell transplant.”  Frontiers Immunology 2020 Oct 16; 11:571884. DOI: 10.3389/fimmu.2020.571884.  PMID: 33193355. Co-First Author*.
  8. Schultz K. Karaminia A, Ng B, Abdossamadi S, Nemecek ER, Wahlstrom JT, Kitko CK, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi S-W, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Flower A, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, Halevy A, Mostafavi S, Cuvelier GDE.  “Immune profile differences between chronic GvHD and late-acute GvHD: Results of the ABLE/PBMTC 1202 Studies”.  Blood 2020.  135(15):1287-1298.  DOI: 10.1182/blood.2019003186.  PMID: 32047896.  Senior Author.
  9. Cuvelier GDE, Nemecek ER, Wahlstrom JT, Kitko CK, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi S-W, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Flower A, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, West LJ, Pan B, Al Hamarneh YN, Halevy A, and Schultz KR.  “Benefits and challenges with diagnosing chronic graft-versus-host disease and late acute graft-versus-host disease in children according to the National Institutes of Health consensus criteria.” (ABLE / PBMTC 1202 study).” Blood 2019.  134(3): 304-316.  DOI: 10.1182/blood.2019000216.  PMID: 31043425.  Corresponding author.
  10. Cuvelier GDE, Rubin TS, Junker A, Sinha R, Rosenberg AM, Wall DA, Schroeder ML.  “Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency.”  Clinical Immunology 2019. 205: 138-147. DOI: 10.1016/j.clim.2018.10.019.  PMID 30391351.  Corresponding author

Area Of Focus

  • Pediatric Hematopoietic Cell Transplant
  • Chronic Graft-Versus-Host Disease in Children
  • Primary Immune Deficiency and Transplant Approaches and Outcomes

Summary Of Research

  1. Bhatt NS, Harris AC, Gorfinkel L, Ibanez K, Tkaczyk ER, Mitchell SA, Albuquerque S, Schecter T, Pavletic S, Duncan CN, Rotz SJ, Williams K, Carpenter PA, Cuvelier GDE. “Pediatric Transplant and Cellular Therapy Consortium RESILIENT conference on pediatric chronic graft-versus-host disease survivorship after hematopoietic cell transplantation: Part I. Phases of chronic GVHD, supportive care, and systemic therapy discontinuation”.  Transplantation and Cellular Therapy.  Feb;31(2):69.e1-69.e18.  DOI: 10.1016/j.jtct.2024.12.011.  PMID: 39701289.  Senior Author.
  2. Pham-Huy A, Murguia-Favela L, Rubin T, Suresh S, Wright NAM, Derfalvi B, Sinha R, Bowes J, Cuvelier GDE. “Inborn errors of immunity in Canadian First Nations and Nunavut Inuit children: The tip of the iceberg”.  Paediatrics & Child Health. 2024.  Jun 13:30(1):40-47.  DOI: 10.1093/pch/pxae026.  PMID: 40061245.    Senior author.
  3. Cuvelier GDE, Ng B, Abdossamadi S, Nemecek ER, Melton A, Kitko CL, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, Ostroumov E, Schultz KR.  “A diagnostic classifier for pediatric chronic graft-versus-host disease: Results of the ABLE / PBMTC 1202 study”.  Blood Advances.  2023 July 25; 7(14):3612-3623.  DOI: 10.1182/bloodadvances.2022007715.  PMID: 36219586.  Corresponding author.
  4. Cuvelier GDE, Logan BR, Prockop SE, Buckley RH, Kuo CY, Griffith LM, Liu X, Yip A, Hershfield MS, Ayoub PG, Moore TB, Dorsey MJ, O’Reilly RJ, Kapoor N, Pai S-Y, Kapadia M, Ebens CL, Forbes-Satter LR, Burroughs LM, Petrovic A, Chellapandian D, Heimall J, Shyr DC, Rayes A, Bednarski JJ, Chandra S, Chandrakasan S, Gillio AP, Madden L, Quigg TC, Caywood EH, Dávila Saldaña BJ, DeSantes K, Eissa H, Goldman FD, Rozmus J, Shah AJ, Vander Lugt MT, Thakar MS, Parrott RE, Martinez C, Leiding JW, Torgerson TR, Pulsipher MA, Notarangelo LD, Cowan MJ, Dvorak CC, Haddad E, Puck JM, Kohn DB.  “Outcomes following treatment for adenosine deaminase deficient severe combined immune deficiency: A report from the PIDTC”.  Blood.  2022.  Aug 18; 140(7):685-705.  DOI: 10.1182/blood.2022016196.  PMID: 35671392.  Corresponding author.
  5. Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, Penack P, Santomasso BD, Zeiser R, Angstwurm K, MacDonald KPA, Kimberly WT, Bilic E, Banas B, Buettner-Herold M, Sinha N, Greinix HT, Pidala J, Schultz KR, Williams KM, Inamoto Y, Cutler C, Lee SJ,  Sarantopoulos S, Pavletic SZ, Wolff D.  “Towards a better understanding of the atypical manifestations of chronic graft-versus-host disease: A report from the 2020 National Institutes of Health Consensus Project Task Force”.  Transplantation and Cellular Therapy.  2022.  Aug; 28(8): 426-445.  DOI: 10.1016/j.jtct.2022.05.038.  PMID: 35662591.  Corresponding author.
  6. Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek E, Rozmus J, Kharbanda S, Kitko C, Lewis V, Schechter T, Jacobsohn D, Harris A, Pulsipher M, Bittencourt H, Choi SW, Caywood E, Kasow K, Bhatia M, Oshrine B, Coulter D, Chewning J, Joyce M, Pawlowska A, Megason G, Lawitschka A, Ostroumov E, Getlinik RK, Cuvelier GDE* and Schultz KR*.  “Metabolomic identification of alpha-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease”. Blood 2022. Jan 13;139(2):287-299. DOI: 10.1182/blood2021013244.  PMID: 34534280. *Co-Senior Author.
  7. Cuvelier GDE*, Li A*, Drissler S, Kariminia A, Abdossamadi S, Rozmus J, Ng B, Mostafavi S, Brinkman R, Schultz KR.  “Age related differences in the biology of chronic graft-versus-host disease after hematopoietic stem cell transplant.”  Frontiers Immunology 2020 Oct 16; 11:571884. DOI: 10.3389/fimmu.2020.571884.  PMID: 33193355. Co-First Author*.
  8. Schultz K. Karaminia A, Ng B, Abdossamadi S, Nemecek ER, Wahlstrom JT, Kitko CK, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi S-W, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Flower A, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, Halevy A, Mostafavi S, Cuvelier GDE.  “Immune profile differences between chronic GvHD and late-acute GvHD: Results of the ABLE/PBMTC 1202 Studies”.  Blood 2020.  135(15):1287-1298.  DOI: 10.1182/blood.2019003186.  PMID: 32047896.  Senior Author.
  9. Cuvelier GDE, Nemecek ER, Wahlstrom JT, Kitko CK, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi S-W, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Flower A, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, West LJ, Pan B, Al Hamarneh YN, Halevy A, and Schultz KR.  “Benefits and challenges with diagnosing chronic graft-versus-host disease and late acute graft-versus-host disease in children according to the National Institutes of Health consensus criteria.” (ABLE / PBMTC 1202 study).” Blood 2019.  134(3): 304-316.  DOI: 10.1182/blood.2019000216.  PMID: 31043425.  Corresponding author.
  10. Cuvelier GDE, Rubin TS, Junker A, Sinha R, Rosenberg AM, Wall DA, Schroeder ML.  “Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency.”  Clinical Immunology 2019. 205: 138-147. DOI: 10.1016/j.clim.2018.10.019.  PMID 30391351.  Corresponding author