Derrick Rancourt is a Professor in the Department of Oncology, Biochemistry & Molecular Biology and Medical Genetics, University of Calgary. He received his BSc and PhD in Biochemistry from the University of Guelph and Queens University respectively and post-doctorate in the laboratory of Nobel Laureate Dr. Mario Capecchi. He is an entrepreneurial scientist and Director of Alberta’s Provincial Genome Engineering Centre. His research program revolves around the derivation, expansion, differentiation and genetic manipulation of mouse and human pluripotent stem cells. Derrick teaches biotechnology business and professional development in the Cumming School of Medicine and is a Director of the Alberta Council of Technologies.
Raincourt, Derrick
Fundamental Research
Professor
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Biography
Area of Focus
Summary of Research
- Nath SC, Day B, Harper L, Yee J Hsu CYM, Larijani, L, Rohani L Duan N, Kallos MS and Rancourt DE. (2021) Fluid shear promotes mESCs pluripotency via interplay between b-catenin and vinculin in bioreactor culture. Stem Cells doi: 10.1002/stem.3382. online ahead of print.
- Helmi S, Rohani L, Rancourt DE. (2021) Enhanced osteogenic differentiation of pluripotent stem cells via γ-secretase inhibition. Int J Mol Sci. 22: 5215.
- Borys BS, Dang T, So T, Rohani L, Ravey T, Walsh T, Argiropoulos B, Rancourt DE, Jung S, Hashimura Y, Lee B and Kallos MS (2020) Overcoming Bioprocess Bottlenecks in the Large-Scale Expansion of High Quality hiPSC Aggregates in Vertical-Wheel Stirred Suspension Bioreactors. Stem Cell Research and Therapy 12: 55.
- Waldner D, Ito K, Chen L, Nguyen L, Chow R, Lee A, Rancourt D, Tremblay F, Stell W, and Bech-Hansen NT (2020) Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A). Transl Vis Sci & Tech 9:19.
- Rohani L, Borys BS, Razian G, Naghsh P, Mahranju P, Johnson AA, Holland H, Liu S, Li J, Kallos MS, Rancourt DE. (2020) Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells. Nat Commun Biol 3: 492.
- Klopp RA and Rancourt DE (2020) Managing Emergent Knowledge: Addressing the Competency Expectations of Biomedical Employers. Can J Career Dev 19: 21-31.
- Borys BS, So T, Colter J, Dang T, Roberts E, Revey T, Larijani L, Krawetz R, Lewis I, Argiropoulos B. Rancourt DE, Jung S, Hashimura Y, Lee B and Kallos MS (2020) Optimized Serial Expansion of Human Induced Pluripotent Stem Cells Using Low Density Inoculation to Generate Clinically Relevant Quantities in Vertical-Wheel Bioreactors. Stem Cell Transl Med 9: 1036-1052.
- Borys BS, So T, Roberts E, Ferrie L, Larijani L, Abraham BD, Krawetz R, Rancourt DE, Kallos MS (2020) Large-Scale Expansion of Feeder-Free Mouse Embryonic Stem Cells Serially Passaged in Stirred Suspension Bioreactors at Low Inoculation Densities Directly from Cryopreservation. Biotechnol Bioeng 117: 1316-1328.
- Cota P, Helmi S, Hsu C and Rancourt DE (2020) Cytokine Directed Chondroblast Trans-Differentiation: JAK Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts. Cells 9: 191
- Rohani L, Machiraju P, Sabouny R, Meng G, Liu S, Zhao T, Iqbal F, Wu J, Khan K, Shutt T, Rancourt DE, Greenway SC. (2020) Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy. Can J Cardiol 36: 554-563.
Area Of Focus
Summary Of Research
- Nath SC, Day B, Harper L, Yee J Hsu CYM, Larijani, L, Rohani L Duan N, Kallos MS and Rancourt DE. (2021) Fluid shear promotes mESCs pluripotency via interplay between b-catenin and vinculin in bioreactor culture. Stem Cells doi: 10.1002/stem.3382. online ahead of print.
- Helmi S, Rohani L, Rancourt DE. (2021) Enhanced osteogenic differentiation of pluripotent stem cells via γ-secretase inhibition. Int J Mol Sci. 22: 5215.
- Borys BS, Dang T, So T, Rohani L, Ravey T, Walsh T, Argiropoulos B, Rancourt DE, Jung S, Hashimura Y, Lee B and Kallos MS (2020) Overcoming Bioprocess Bottlenecks in the Large-Scale Expansion of High Quality hiPSC Aggregates in Vertical-Wheel Stirred Suspension Bioreactors. Stem Cell Research and Therapy 12: 55.
- Waldner D, Ito K, Chen L, Nguyen L, Chow R, Lee A, Rancourt D, Tremblay F, Stell W, and Bech-Hansen NT (2020) Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A). Transl Vis Sci & Tech 9:19.
- Rohani L, Borys BS, Razian G, Naghsh P, Mahranju P, Johnson AA, Holland H, Liu S, Li J, Kallos MS, Rancourt DE. (2020) Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells. Nat Commun Biol 3: 492.
- Klopp RA and Rancourt DE (2020) Managing Emergent Knowledge: Addressing the Competency Expectations of Biomedical Employers. Can J Career Dev 19: 21-31.
- Borys BS, So T, Colter J, Dang T, Roberts E, Revey T, Larijani L, Krawetz R, Lewis I, Argiropoulos B. Rancourt DE, Jung S, Hashimura Y, Lee B and Kallos MS (2020) Optimized Serial Expansion of Human Induced Pluripotent Stem Cells Using Low Density Inoculation to Generate Clinically Relevant Quantities in Vertical-Wheel Bioreactors. Stem Cell Transl Med 9: 1036-1052.
- Borys BS, So T, Roberts E, Ferrie L, Larijani L, Abraham BD, Krawetz R, Rancourt DE, Kallos MS (2020) Large-Scale Expansion of Feeder-Free Mouse Embryonic Stem Cells Serially Passaged in Stirred Suspension Bioreactors at Low Inoculation Densities Directly from Cryopreservation. Biotechnol Bioeng 117: 1316-1328.
- Cota P, Helmi S, Hsu C and Rancourt DE (2020) Cytokine Directed Chondroblast Trans-Differentiation: JAK Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts. Cells 9: 191
- Rohani L, Machiraju P, Sabouny R, Meng G, Liu S, Zhao T, Iqbal F, Wu J, Khan K, Shutt T, Rancourt DE, Greenway SC. (2020) Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy. Can J Cardiol 36: 554-563.